Are you running TPA in portrait mode?
Otherwise I wouldn't know how this could be an issue - my GTX670 handles 4K downsampled to 1920x1200 with 4xFSAA, 16x Anisotropic and 2x Transparency AA just fine at 60fps with v-sync (non-portrait though) and it could probably handle more FSAA (hardly more than 60% GPU usage with my settings) if it would not run out of memory with higher FSAA settings.
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